Documentation is important to demonstrate system validation. The documentation should include a written design of what the system is intended to do and how it will do it.
Process Validation is a legal requirement and enforceable under the following guidelines: 501(a)(2)(b) of FD&C Act and cGMP guidance –ICH Q7 and ISO 13485.
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In essence, 21 CFR Part 11 addresses how any electronic data and associated records generated within the regulated environment are to be properly stored, secured, archived, validated and maintained. 21 CFR Part 11 directly applies to all FDA’s regulated segments, with GLP and GMP, and has hence been enforced by regulatory centers such as CDER and CBER.
A written validation or test plan should be developed to include structural and functional analysis.